Showing 1–16 of 17 results
Generic Name: Neomycin ( as Sulfate ) / Polymyxin B ( as Sulfate )/ Bacitracin
Trade Name: B.N.P Manufacturer: Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals, Inc.
Pharmacologic Classification: Topical Antibiotics
Mechanism of Action: Neomycin: Within the cell they bind to 30s and to some extent to the 50s subunits of the bacterial ribosome, inhibiting protein synthesis and generating errors in the transcription of the genetic code. Polymyxin: acts primarily by binding to membrane phospholipids and disrupting the bacterial cytoplasmic membrane. Bacitracin: it interferes with bacterial cell wall synthesis by blocking the function of the lipid carer molecule that transfers cell wall subunits across the cell membrane.
Therapeutic Indication: Used therapeutically for bacterial infections due to susceptible organism as in impetigo, ecthyma, sycosis vulgaris, otitis extema, paronychia, and for secondarily infected dermatoses, such as eczema, herpes or seborthoeic dermatitis. Dosage Forms & Strength : 5mg/ 5,000 units/ 400 units Ointment
Pharmacokinetics: Neomycin: Absorbed in wounds and inflamed skin. Once absorbed it is rapidly Excreted by the kidneys in active form. Polymyxin: it is not absorbed from the gastro-intestinal tract, except in the newbom. It is not also absorbed through the intact skin. It is excreted mainly by the kidneys, up to 60% being recovered in the urine but there is a time lag of 12 to 24 hours before polymyxin is recovered in the urine. Bacitracin: Absorption following topical application is minimal.
Dosage and Administration: The ointment should be applied to the affected area 2-5 times daily, or as directed by the physician. Adverse Reactions: Local application of antibiotics, including neomycin and bacitracin, has been Associated with severe allergic disorders, e.g. generalized itching, swelling of the face, sweating, tightness of the chest and hypotension. The possibility of such reactions should be bome in mind. Prolonged use should be avoided as it may lead to skin sensitation.
Contraindications: Contraindicated to patients with hypersensitivity to any of its components.
Storage Condition: Store below 25°C.
Generic Name: Ofloxacin
Trade Name: Dizoflox
Manufacturer: Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals, Inc.
Pharmacologic Classification: Fluoroquinolone Ear Anti-infectives
Mechanism of Action: Ofloxacin has in vitro activity against a wide range of gram- negative and gram-positive microorganisms. Ofloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription.
Therapeutic Indication : Indicated for the treatment of external otic infections caused by Staphylococcus Spp., Streptococcus spp., Enterococcus spp., Corynebacterium spp., and Gram negative bacteria like P. aeruginosa, H. influenza, E. coli, Citrobacter spp., Klebsiella spp., Enterobacter spp., Providencia spp., S. marescens, Proteus spp., and anaerobes.
Dosage Forms & Strength: 3mg/mL (0.3%)
Pharmacokinetics: Studies have shown that a single administration of 10 drops of Oflocaxin 0.3% otic solution in adult patients with otic infections yielded serum ofloxacin concentrations of –<0.017 ug/mL and -<0.007 ug/mL after 30minutes and 1 hour respectively. Ten drops of 0.3% ofloxacin otic solution applied twice daily for 7 days showed a serum concentration of -<0.012 ug/mL 30minutes after every administration.
Dosage and Administration: Tilt head sidewards to allow infected otic to face up and instill 1-2 drops of Ofloxacin otic solution twice daily for 7 days for a maximum of 14 days, morning and evening into the affected otic. Prevent the tip of the container from touching the otic. Keep head tilted up to 5 minutes and remove excess solution with a clean cotton. Or as prescribed by the physician.
Adverse Reactions: Hypersensitivity reaction, otalgia, tinnitus & itchiness Contraindications: Hypersensitivity to Ofloxacin
Storage Condition: Store at temperature not exceeding 300 C.
Generic Name: Ofloxacin
Trade Name: Dizoflox
Manufacturer: Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals Inc.
Pharmacologic Classification: Fluoroquinolone Eye Anti-infectives
Mechanism of Action: Ofloxacin has in vitro activity against a wide range of gram- negative and gram-positive microorganisms. Ofloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential bacterial enzyme which is a critical catalyst in the duplication, transcription, and repair of bacterial DNA.
Therapeutic Indication: It is indicated for the treatment of external eye infections such as blepharitis, hordeolum, dacryocystitis, conjunctivitis, meibomitis, keratitis, trachoma, and for the prevention of infection following corneal ulceration.
Dosage Forms & Strength: 3mg/mL (0.3%) Ophthalmic Solution
Dosage and Administration: Instill 1 to 2 drops twice daily for 7 days to a maximum of 2 weeks or as prescribed by the physician.
Adverse Reactions: Irritation and stinging effect
Contraindications: It is contraindicated in patients with a history of hypersensitivity to ofloxacin, to other quinolones, or to any of the components in this medication.
Storage Condition: Store at temperature not exceeding 300
Generic Name: Doxycycline Hydrochloride
Trade Name: Doxicon
Manufacturer: Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals, Inc.
Pharmacologic Classification: Tetracycline Antibiotic
Generic Name: Miconazole nitrate
Trade Name: Fungtopic Manufacturer – Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals, Inc.
Pharmacologic Classification: Topical Antifungal
Mechanism of Action: Miconazole has an in vitro activity against Cladosporium, Madurella and Phialophora spp. and against Pseudallescheria boydii , and Gram-positive bacteria including some staphylococci and streptococci.
Therapeutic Indication: Indicated for the topical treatment of fungal infections of the skin, hair, nails, as well as superinfection due to gram-positive bacteria.
Dosage Forms & Strength: 20mg/g (2% wiw) Cream Pharmacokinetics: There is a little absorption through skin or mucous membranes when miconazole nitrate is applied.
Dosage and Administration: When used in skin infections, apply the cream thinly into the lesion twice daily with gentle rubbing and should be continued for 10 days after the disappearance of all lesions. For nail infections, apply the cream sparingly to the affected area once daily.
Adverse Reactions: Local irritation and sensitivity reactions may occur when miconazole nitrate is used Topically; contact dermatitis have also been reported. Contraindications : Hypersentivity to miconazole.
Storage Condition: Store below 25°C.
Generic name: Polymyxin B sulfate,
Formulation: Neomycin sulfate, Hydrocortisone ( as acetate )
Each ml contains: Polymyxin B sulfate 10,000 Units Neomycin sulfate 3,400 Units, Hydrocortisone 10 mg
Classification: Ear Antiseptic with Corticosteriods
Indications: Anti-inflammatory and Anti-infective in the treatment of dermatoses of the ear due to allergic, neurogenic and seborrhoeic factors. Otitis media and in the management of cavities after mastoidectomy and fenestration operation.
Dosage: Instill into the affected ear(s) with the head tilted to one side 3 drops 3 – 4 times daily. The position should be maintained for a few minutes.
Contraindications: Hypersensitivity to any of the components of the Ear Drops.
Warnings: In case of chronic otitis media and where the ear drum is perforated, the drops should be used with care and for short periods only because of the risk of the ototoxicity. As with other antibiotics, prolonged use may result in overgrowth of non susceptible organisms.
Storage: Store below 250 C.
Availability: 5 mL white dropper bottle
Generic Name: Hydrocortisone
Trade Name: Hydrotopic
Manufacturer: Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals, Inc.
Pharmacologic Classification: Topical Corticosteroids
Mechanism of Action: Hydrocortisone is a corticosteroid used for its anti- inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability.
Therapeutic Indication: Relief of symptoms in acute & chronic dermatoses example eczema, infantile eczema, contact dermatitis, neurodermatitis, psonasis, pruntus.
Dosage Forms & Strength: 10 mo/g (1% w/w) Cream Pharmacokinetics: Hydrocortisone is absorbed through the skin, particularly in denuded areas. Hydrocortisone is metabolized in the liver and most body tissues to hydrogenated and Degraded forms such as tetrahydrocortisone and tetra hydrocortisol. These are excreted in the urine, mainly conjugated as glucuronides, together with a very small proportion of unchanged hydrocortisone.
Dosage and Administration: Apply into the cleansed affected skin 3 to 4 times daily or as directed by the physician.
Adverse Reactions: Itching, dryness, irritations, acneform eruptions and buming sensations, maceration of the skin, secondary infections, skin atrophy, striae and miliana.
Contraindications: The topical use of Hydrocortisone 10mg/g cream is contraindicated in the presence of skin infections of bacterial or fungal origin. Hypersensitivity to the adrenal corticosteroids is an obvious contraindication.
Storage Condition: Protect from light. Store at temperature not exceeding 30°C.
Generic Name: Hypromellose
Trade Name: Hypromax
Manufacturer: Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals Inc.
Pharmacologic Classification: Ophthalmic Lubricant
Mechanism of Action: It acts to stabilize and thicken the pre corneal tear film and prolong the tear film breakup time which is usually accelerated in patients with dry eye states. It also acts to lubricate and protect the eye. It usually reduces the signs and symptoms resulting from moderate to severe dry eye syndromes
Therapeutic Indication: Ophthalmic Lubricant
Dosage Forms & Strength: 3mg/mL (0.3%) Sterile Ophthalmic Solution
Dosage and Administration: Instill 1-2 drops in each eye. For contact lenses apply a few drops before insertion. Adverse Reactions: Eye discomfort/irritation/redness, tearing, temporary blurred vision.
Storage Condition: Protect from light. Store at temperature not exceeding 300 C.
Generic Name: Polymyxin B sulfate
Formulation: Neomycin sulfate Dexamethasone
Each ml contains: Polymyxin B sulfate – 6000 Units, Neomycin sulfate – 5 mg, Dexamethasone ( as Sodium Phosphate ) – 1 mg
Indication: Management of ocular infections and inflammations produced by organisms which are sensitive to Neomycin and Polymyxin B sulfate. Acute or chronic non-purulent conjunctivitis, kerato-conjunctivitis, nonspecific superficial keratitis, Herpes zoster ophthalmicus, mild acute iritis, iridocyclitis, corneal ulcer, non-purulent blepharitis, scleritis, post-operatively to prevent ocular infection.
Dosage: Instill 1 – 2 drops in the conjunctival sacs 4 – 6 times daily. Dosage may be reduced after 3 to 4 days when a satisfactory response has been obtained.
Contraindications: This eye drop is contraindicated in tuberculous, fungal and most viral lesions of the eyes. Also in those patients who have shown hypersensitivity to any of its components.
Warning: Contains Sodium Metabisulfite, a sulfite that may cause allergic-type reactions
including anaphylactic symptoms and life threatening or less severe asthmatic episodes in certain susceptible individuals.
Storage: Store below 250 C.
Maxoptic Eye Drops is a sterile, buffered, and isotonic solution.
Generic Name: Polymyxin B sulfate,
Formulation: Neomycin sulfate Gramicidin
Each ml contains: Polymyxin B sulfate 5,000 Units Neomycin sulfate 1,700 Units Gramicidin 25 Units
Classification: Eye Anti-infectives and Antiseptics
Indications: For the prophylaxis and treatment of externalbacterial infections of the eye including conjunctivitis, blepharitis, keratitis, corneal ulcers, styes, abrations and lacerations.
Dosage: Instill 1 – 2 drops 2 – 4 times daily. In acute infections, therapy may be repeated every 15 to 30 minutes until infection is controlled.
Contraindications: Hypersensitivity to any of the components of the Ophthalmic Solutions.
Storage: Store below 250 C. Protect from light.
Availability: Box of 12’s
Contents: Calcium Carbonate + Vitamin D3
Trade Name: Osteoprotec
Manufacturer: Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals Inc.
Pharmacologic Classification: Food Supplement
Generic Name: Neomycin Sulfate / Dexamethasone sodium phosphate/ Polymyxin B Sulfate
Trade Name: OTIXIN
Manufacturer: Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals, Inc.
Pharmacologic Classification: Ear Antiseptics with Corticosteroids
Therapeutic Indication: For the treatment of ear infections due to susceptible gram-positive and gram-negative organisms, especially Staphylococci and Pseudomonas aeruginosa; and for the management of the inflammation caused by these infections.
Dosage Forms & Strength: 5mg/ 1mg /10,000units Otic Solution (Drops)
Dosage and Administration: Initially three to four drops 2-3 times a day, then may be reduced gradually or as prescribed by the physician
Adverse Reactions: Long term use may cause ototoxicity
Contraindications: Infectious tuberculosis lesions of the ear, chickenpox. Vaccina & herpes simplex. Hypersensitivity
Storage Condition: Store at temperature not exceeding 30°C
TGeneric Name: Silver Sulfadiazine
Trade Name: Stenizol Manufacturer : Ashford Pharmaceutical Laboratories, |nc.
Source of Supply: Vendiz Pharmaceuticals, Inc.
Pharmacologic Classification: Topical Antibiotics Mechanism of Action: Silver sulfadiazine has a broad antimicrobial activity against Gram- negative bacteria including Pseudomonas aeruginosa and some yeast and fungi. It has a bactericidal action; in contrast to sulfadiazine, the silver salt acts primarily on the cell membrane and cell wall and its action Is not antagonized by p-aminobenzoic acid.
Therapeutic Indication: Silver sulfadiazine is a Sulphonamide which is used, in conjunction with debridement, as a 1% cream for the prevention and treatment of infection in severe bums. It is also being used in other skin conditions, such as leg ulcers, where infection may prevent healing and for the prophylaxis of infection in skin grafting.
Dosage Forms & Strength: 10mg/g (1% wiw) Cream
Pharmacokinetics: Silver sulfadiazine is slowly converted to sulfadiazine in contact with wound exudates. Up to about 10% of the sulfadiazine may be absorbed; concentrations in the blood of 10 to 20ug per mL have been reported, although higher concentrations may be achieved when extensive areas of the body is treated. Probably not more than 1% of the silver content is absorbed.
Dosage and Administration: In bums, apply once or twice daily to a thickness of approximately 1/16 inch. In leg ulcers, apply at least 3 times a week or as prescribed by the physician.
Adverse Reactions: Local reactions have been reported in a small percentage of patients. Systemic absorption of Silver Sulfadiazine may occur and prolonged use should be avoided.
Contraindications: Contraindicated for patients with hypersensitivity to sulfonamides.
Storage Condition: Store below 25°C.
Generic name: Betamethasone valerate
Trade Name: Steroderm
Manufacturer: Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals. Inc.
Pharmacologic Classification: Topical Corticosteroids
Mechanism of Action: Betamethasone is a corticosteroid with mainly glucoccoid activity. It prevents and controls inflammation by controlling the rate ol protein synthesis, depressing the migration of polymcrphonuclear leukocytes and fibroblasts, and reversing capillary permeability and lysosomal
stabilisation.
Therapeutic lndication: Effective treatment for more difficult conditions such as psoriasis, and lichen planus. Eczema including atopic, infantile, dlscoid statis eczema and prurigo. Seborheic dermatitis, contact sensitivity reactions and allergies, discoid lupus erythematosus. The anti-inflammatory effect of Betamethasone Valerate cream is useful in the management of: otitis extema, anal and vul’,/al prJitus, lnsect bites, prickly heat, sunburn.
Dosage Forms & Stength: 1mg/g (0.1% Mw) Cream
Pharmacokinetics: Betamethasone when applied topically, particularly under an occlusive dressing or when the skin is broken, sumcient cor costeroids may be absorbed to give syster,ic effects. lt is metabolized in the liver and distributed throughout body tissues; crosses the placenta and enters the breast milk. Excretion is via urine.
Dosage and Administration: A small quantity should be applied gently to the affected area 2-3 times daily until improvement occurs. lt may then be possible to maintain progressive improvement using one application day or even less often. The water- miscible cream may be preferable for moist or weeplng surfaces, but for dry lesions the more emollient ointment is often more satisfactory.
Contraindications: Betamethasone valerate cream is usually well tolerated, but if signs of Hypersensitivity appear, application should stop immediately. Any spread of infection on the skin requires withdrawal of topical corticosteroid therapy. prolonged and intensive treatment with highly active corticosteroids preparations may cause local atrophic
changes in the skin such as striae, thinning and dilation of the superficial blood vessels, particularly when occlusive dressings are used or where skin folds are involved. As with other topical corticosteroids, when extensive areas are treated, sufficient systemic absorption may occur to produce the features of hypercodcism. This effect is more likely to occur in infants and children, and if occlusive dressing are used. In infants, the diapers may act as an occlusive dressing.
Contraindications : Viral diseases of the skin, e.g. herpes simplex. Contraindicated in patients with history of hypersenitivity to any of the components of the preparation.
Generic Name: Neomycin / Triamcinolone acetonide/ Gramicidin / Nystatin
Trade Name: Vendicom Manufacturer : Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals, Inc.
Pharmacologic Classification: Ear Antiseptics with Cortecosteroids
Mechanism of Action: Nystatin acts by binding to steroids in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated sub culturing with increasing levels of Nystatin, Candida albicans does not develop resistance to Nystatin. Generally, resistance to Nystatin does not develop during therapy. Nystatin Exhibits no activity against bacteria, protozoa or viruses. Neomycin exerts its antibacterial activity against a number of Gram negative organisms by inhibiting protein synthesis. It is not active against Pseudomonas aeruginosa, and resistant strains of Gram negative bacteria may develop. Gramicidin exerts its antibacterial activity against many Gram positive organism by altering cell membrane permeability.
Therapeutic Indication: For the treatment of otitis externa ( acute and chronic) when a topical corticosteroid is required and active infections with susceptible organisms are either present or likely to supervene. It is recommended for short term use.
Dosage Forms & Strength: 2.5mg/1mg/250mcg/100,000 units per mL
Generic Name: Prednisolone Acetate
Trade Name: Venpred
Manufacturer: Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals, Inc.
Pharmacologic Classification: Eye Corticosteroids
Mechanism of Action: Corticosteroids inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation.
There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from the membrane phospholipids by phospholipase A2.
Therapeutic Indication: For steroid responsive inflammation and allergic ocular conditions, inflammatory keratitis and otherinflammatory disorders of the anterior segments of the globe.
Dosage Forms & Strength: 10mg/mL Ophthalmic Suspension
Dosage and Administration: One to two drops twice a day to four times a day or as prescribed by a physician.
Adverse Reactions: Increased intraocular pressure with optic nerve damage, visual field defects. Systemic side effects may occur with extensive use of steroids.
Contraindications: Acute superficial herpes simplex keratitis; systemic fungal infections; varicella; Hypersensitivity to prednisolone
Storage Condition: Store at temperatures not exceeding 300 C.