B.N.P. Ointment

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Neomycin / Polymyxin B / Bacitracin

Generic Name: Neomycin ( as Sulfate ) / Polymyxin B ( as Sulfate )/ Bacitracin
Trade Name: B.N.P Manufacturer: Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals, Inc.
Pharmacologic Classification: Topical Antibiotics
Mechanism of Action: Neomycin: Within the cell they bind to 30s and to some extent to the 50s subunits of the bacterial ribosome, inhibiting protein synthesis and generating errors in the transcription of the genetic code. Polymyxin: acts primarily by binding to membrane phospholipids and disrupting the bacterial cytoplasmic membrane. Bacitracin: it interferes with bacterial cell wall synthesis by blocking the function of the lipid carer molecule that transfers cell wall subunits across the cell membrane.
Therapeutic Indication: Used therapeutically for bacterial infections due to susceptible organism as in impetigo, ecthyma, sycosis vulgaris, otitis extema, paronychia, and for secondarily infected dermatoses, such as eczema, herpes or seborthoeic dermatitis. Dosage Forms & Strength : 5mg/ 5,000 units/ 400 units Ointment
Pharmacokinetics: Neomycin: Absorbed in wounds and inflamed skin. Once absorbed it is rapidly Excreted by the kidneys in active form. Polymyxin: it is not absorbed from the gastro-intestinal tract, except in the newbom. It is not also absorbed through the intact skin. It is excreted mainly by the kidneys, up to 60% being recovered in the urine but there is a time lag of 12 to 24 hours before polymyxin is recovered in the urine. Bacitracin: Absorption following topical application is minimal.
Dosage and Administration: The ointment should be applied to the affected area 2-5 times daily, or as directed by the physician. Adverse Reactions: Local application of antibiotics, including neomycin and bacitracin, has been Associated with severe allergic disorders, e.g. generalized itching, swelling of the face, sweating, tightness of the chest and hypotension. The possibility of such reactions should be bome in mind. Prolonged use should be avoided as it may lead to skin sensitation.
Contraindications: Contraindicated to patients with hypersensitivity to any of its components.
Storage Condition: Store below 25°C.