Sterizol Cream

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Silver Sulfadiazine

TGeneric Name: Silver Sulfadiazine
Trade Name: Stenizol Manufacturer : Ashford Pharmaceutical Laboratories, |nc.
Source of Supply: Vendiz Pharmaceuticals, Inc.
Pharmacologic Classification: Topical Antibiotics Mechanism of Action: Silver sulfadiazine has a broad antimicrobial activity against Gram- negative bacteria including Pseudomonas aeruginosa and some yeast and fungi. It has a bactericidal action; in contrast to sulfadiazine, the silver salt acts primarily on the cell membrane and cell wall and its action Is not antagonized by p-aminobenzoic acid.
Therapeutic Indication: Silver sulfadiazine is a Sulphonamide which is used, in conjunction with debridement, as a 1% cream for the prevention and treatment of infection in severe bums. It is also being used in other skin conditions, such as leg ulcers, where infection may prevent healing and for the prophylaxis of infection in skin grafting.
Dosage Forms & Strength: 10mg/g (1% wiw) Cream
Pharmacokinetics: Silver sulfadiazine is slowly converted to sulfadiazine in contact with wound exudates. Up to about 10% of the sulfadiazine may be absorbed; concentrations in the blood of 10 to 20ug per mL have been reported, although higher concentrations may be achieved when extensive areas of the body is treated. Probably not more than 1% of the silver content is absorbed.
Dosage and Administration: In bums, apply once or twice daily to a thickness of approximately 1/16 inch. In leg ulcers, apply at least 3 times a week or as prescribed by the physician.
Adverse Reactions: Local reactions have been reported in a small percentage of patients. Systemic absorption of Silver Sulfadiazine may occur and prolonged use should be avoided.
Contraindications: Contraindicated for patients with hypersensitivity to sulfonamides.
Storage Condition: Store below 25°C.