Hydrotopic Cream

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Generic Name: Hydrocortisone
Trade Name: Hydrotopic
Manufacturer: Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals, Inc.
Pharmacologic Classification: Topical Corticosteroids
Mechanism of Action: Hydrocortisone is a corticosteroid used for its anti- inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability.
Therapeutic Indication: Relief of symptoms in acute & chronic dermatoses example eczema, infantile eczema, contact dermatitis, neurodermatitis, psonasis, pruntus.
Dosage Forms & Strength: 10 mo/g (1% w/w) Cream Pharmacokinetics: Hydrocortisone is absorbed through the skin, particularly in denuded areas. Hydrocortisone is metabolized in the liver and most body tissues to hydrogenated and Degraded forms such as tetrahydrocortisone and tetra hydrocortisol. These are excreted in the urine, mainly conjugated as glucuronides, together with a very small proportion of unchanged hydrocortisone.
Dosage and Administration: Apply into the cleansed affected skin 3 to 4 times daily or as directed by the physician.
Adverse Reactions: Itching, dryness, irritations, acneform eruptions and buming sensations, maceration of the skin, secondary infections, skin atrophy, striae and miliana.
Contraindications: The topical use of Hydrocortisone 10mg/g cream is contraindicated in the presence of skin infections of bacterial or fungal origin. Hypersensitivity to the adrenal corticosteroids is an obvious contraindication.
Storage Condition: Protect from light. Store at temperature not exceeding 30°C.