Generic Name: Prednisolone Acetate
Trade Name: Venpred
Manufacturer: Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals, Inc.
Pharmacologic Classification: Eye Corticosteroids
Mechanism of Action: Corticosteroids inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation.
There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from the membrane phospholipids by phospholipase A2.
Therapeutic Indication: For steroid responsive inflammation and allergic ocular conditions, inflammatory keratitis and otherinflammatory disorders of the anterior segments of the globe.
Dosage Forms & Strength: 10mg/mL Ophthalmic Suspension
Dosage and Administration: One to two drops twice a day to four times a day or as prescribed by a physician.
Adverse Reactions: Increased intraocular pressure with optic nerve damage, visual field defects. Systemic side effects may occur with extensive use of steroids.
Contraindications: Acute superficial herpes simplex keratitis; systemic fungal infections; varicella; Hypersensitivity to prednisolone
Storage Condition: Store at temperatures not exceeding 300 C.
