Generic Name: Neomycin / Triamcinolone acetonide/ Gramicidin / Nystatin
Trade Name: Vendicom Manufacturer : Ashford Pharmaceutical Laboratories, Inc.
Source of Supply: Vendiz Pharmaceuticals, Inc.
Pharmacologic Classification: Ear Antiseptics with Cortecosteroids
Mechanism of Action: Nystatin acts by binding to steroids in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated sub culturing with increasing levels of Nystatin, Candida albicans does not develop resistance to Nystatin. Generally, resistance to Nystatin does not develop during therapy. Nystatin Exhibits no activity against bacteria, protozoa or viruses. Neomycin exerts its antibacterial activity against a number of Gram negative organisms by inhibiting protein synthesis. It is not active against Pseudomonas aeruginosa, and resistant strains of Gram negative bacteria may develop. Gramicidin exerts its antibacterial activity against many Gram positive organism by altering cell membrane permeability.
Therapeutic Indication: For the treatment of otitis externa ( acute and chronic) when a topical corticosteroid is required and active infections with susceptible organisms are either present or likely to supervene. It is recommended for short term use.
Dosage Forms & Strength: 2.5mg/1mg/250mcg/100,000 units per mL
